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|Type:||Artigo de periódico|
|Title:||Detection of polyhydroxyalkaloids in Lonchocarpus extracts by GC-MS of acetylated derivatives|
|Abstract:||The methanol extracts of the roots of Lonchocarpus cultratus, L latifolius and L subglaucescens, species native to Brazil, were all active in the brine shrimp lethality test. Fractions rich in polyhydroxylated alkaloids were obtained from these extracts and, following acetylation, were analysed by GC-MS leading to the identification of acetylated derivatives of 2,5-trans-dihydroxymethyl-3,4-trans-dihydroxypyrrolidine (1), 1-deoxymannojirimycin, 1-deoxynojirimycin, fagomine and homonojirimycin. Only from L. subglaucescens could a compound with the constitution and relative configuration expected for the penta-acetate of 1 be isolated, and its molecular structure was determined for the first time through extensive spectral data analysis. Copyright (C) 2002 John Wiley Sons, Ltd.|
brine shrimp lethality test
|Editor:||John Wiley & Sons Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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