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Type: Artigo de periódico
Title: Red Blood Cell Transfusions are Independently Associated with Intra-Hospital Mortality in Very Low Birth Weight Preterm Infants
Author: SANTOS, Amelia Miyashiro Nunes dos
ALMEIDA, Maria Fernanda Branco de
LEONE, Clea Rodrigues
MARBA, Sergio Tadeu Martins
RUGOLO, Ligia Maria Suppo de Souza
FIORI, Humberto Holmer
LOPES, Jose Maria de Andrade
MARTINEZ, Francisco Eulogio
Brazilian Network Neonatal Res
Abstract: Objective To test the hypothesis that red blood cell (RBC) transfusions in preterm infants are associated with increased intra-hospital mortality. Study design Variables associated with death were studied with Cox regression analysis in a prospective cohort of preterm infants with birth weight <1500 g in the Brazilian Network on Neonatal Research. Intra-hospital death and death after 28 days of life were analyzed as dependent variables. Independent variables were infant demographic and clinical characteristics and RBC transfusions. Results Of 1077 infants, 574 (53.3%) received at least one RBC transfusion during the hospital stay. The mean number of transfusions per infant was 3.3 +/- 3.4, with 2.1 +/- 2.1 in the first 28 days of life. Intra-hospital death occurred in 299 neonates (27.8%), and 60 infants (5.6%) died after 28 days of life. After adjusting for confounders, the relative risk of death during hospital stay was 1.49 in infants who received at least one RBC transfusion in the first 28 days of life, compared with infants who did not receive a transfusion. The risk of death after 28 days of life was 1.89 times higher in infants who received more than two RBC transfusions during their hospital stay, compared with infants who received one or two transfusions. Conclusion Transfusion was associated with increased death, and transfusion guidelines should consider risks and benefits of transfusion. (J Pediatr 2011; 159: 371-6).
Country: Estados Unidos
Citation: JOURNAL OF PEDIATRICS, v.159, n.3, p.371-U220, 2011
Rights: fechado
Identifier DOI: 10.1016/j.jpeds.2011.02.040
Date Issue: 2011
Appears in Collections:FCM - Artigos e Outros Documentos

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