Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61191
Type: Artigo de periódico
Title: Lateralization of epileptiform discharges in patients with epilepsy and precocious destructive brain insults
Author: Teixeira, RA
Li, LM
Santos, SLM
Amorim, BL
Etchebehere, ECS
Zanardi, VA
Guerreiro, CAM
Cendes, F
Abstract: Unilateral destructive brain lesions of early development can result in compensatory thickening of the ipsilateral cranial vault. The aim of this study was to determine the frequency of these bone changes among patients with epilepsy and precocious destructive lesions, and whether a relationship exists between these changes and epileptiform discharges lateralization. Fifty-one patients had their ictal/inter-ictal scalp EEG and skull thickness symmetry on MRI analyzed. Patients were divided into three main groups according to the topographic distribution of the lesion on the MRI: hemispheric (H) (n=9); main arterial territory (AT) (n=25); arterial borderzone (Bdz) (n=17). The EEG background activity was abnormal in 26 patients and were more frequent among patients of group H (p=0.044). Thickening of the skull was more frequent among patients of group H (p=0.004). Five patients (9.8%) showed discordant lateralization between epileptiform discharges and structural lesion (four of them with an abnormal background, and only two of them with skull changes). in one of these patients, ictal SPECT provided strong evidence for scalp EEG false lateralization. The findings suggest that compensatory skull thickening in patients with precocious destructive brain insults are more frequent among patients with unilateral and large lesions. However, EEG lateralization discordance among these patients seems to be more related to EEG background abnormalities and extent of cerebral damage than to skull changes.
Subject: hemiatrophy
infarct
MRI
EEG
Dyke-Davidoff-Masson syndrome
Country: Brasil
Editor: Assoc Arquivos De Neuro- Psiquiatria
Rights: aberto
Identifier DOI: 10.1590/S0004-282X2004000100001
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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