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Type: Artigo de periódico
Title: Jacobsen catalyst as a P450 biomimetic model for the oxidation of an antiepileptic drug
Author: Mac Leod, TCO
Barros, VP
Faria, AL
Schiavon, MA
Yoshida, IVP
Queiroz, MEC
Assis, MD
Abstract: In this work, we investigated carbamazepine (CBZ) oxidation by 3-chloroperoxybenzoic acid (m-CPBA), tert-butyl hydroperoxide 70 wt.% (t-BuOOH) or hydrogen peroxide 30 wt.%, mediated by a salen complex in homogeneous medium or encapsulated in a polymeric matrix based on poly(dimethylsiloxane) (PDMS). The formation of carbarnazepine 10, 11-epoxide (CBZ-EP) is highly dependent on the oxidant, pH, solvent and co-catalyst. CBZ oxidation by m-CPBA, t-BuOOH and H2O2 is more efficient at low pH values, although the pH influence is small in the case of m-CPBA and t-BuOOH, in the entire pH range. This shows that the presence of substituents linked to the -OOH group of m-CPBA and t-BuOOH affects the catalytic activity of the studied system significantly. The encapsulated Jacobsen catalyst proved to be an efficient catalyst for carbarnazepine oxidation by the oxidants t-BuOOH and m-CPBA. However, the hybrid polymeric membrane acted as a barrier against the oxidant H2O2, preventing it from reaching the bulk of the membrane, making substrate oxidation impossible in this case. (C) 2007 Elsevier B.V. All rights reserved.
Subject: carbamazepine
salen complex
biomimetic models
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.molcata.2007.04.003
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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