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Type: Artigo de periódico
Title: Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots
Author: Fernandes, ED
Rodrigues, FA
Tofoli, D
Imamura, PM
de Carvalho, JE
Ruiz, ALTG
Foglio, MA
Minguzzi, S
Silva, RCL
Abstract: The cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and characterized by spectroscopic techniques (NMR of H-1, C-13 and IR). The in vitro antiproliferative activity of jatrophone showed selectivity in a concentration dependent way with Total Inhibition growth of: glioma 0.57 mu g mL(-1) (U251), breast cancer 9.2 mu g mL(-1) (MCF-7), adriamycin-resistant ovarian cancer 0.96 mu g mL(-1) (NCI-ADR/RES), kidney 4.2 mu g mL(-1) (786-0), prostate cancer 8.4 mu g mL(-1) (PC-3), colon cancer 16.1 mu g mL(-1) (HT29) and leukemia 0.21 mu g mL(-1) (K-562).
Subject: cytotoxic activity
Jatropha ribifolia
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2013005000026
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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