Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60847
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBento, Antonio Carlospt_BR
dc.contributor.authorunicampMarangoni, Sérgiopt_BR
dc.contributor.authorunicampRego, Evandro Jose Limapt_BR
dc.contributor.authorunicampNovello, Jose Camillopt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.typeArtigopt_BR
dc.titleIsolation of a polypeptide from phoneutria nigriventer spider venom responsible for the increased vascular permeability in rabbit skinpt_BR
dc.title.alternativeen
dc.contributor.authorMancuso, L. C.pt_BR
dc.contributor.authorGiglio, J.R.pt_BR
dc.contributor.authorBento, A. C.pt_BR
dc.contributor.authorMarangoni, S.pt_BR
dc.contributor.authorRego, E.pt_BR
dc.contributor.authorNovello, J.C.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.contributor.authorOliveira, B.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorPedroso-Mariani, S.R.pt_BR
dc.contributor.authorCaracelli, I.pt_BR
dc.subjectSequência de aminoácidospt_BR
dc.subjectCromatografiapt_BR
dc.subjectPeptídeo hidrolasespt_BR
dc.subjectVenenos de aranhapt_BR
dc.subject.otherlanguageAmino acid sequencept_BR
dc.subject.otherlanguageChromatographypt_BR
dc.subject.otherlanguagePeptide hydrolasespt_BR
dc.subject.otherlanguageSpider venomspt_BR
dc.description.abstractFractionation of Phoneutria nigriventer venom by Sephadex G-10 followed by ion-exchange chromatography yields a fraction (fraction XIII) which increases microvascular permeability in rabbit skin in vivo by activating the tissue kallikrein-kinin system. One polypeptide (PNV3) with the ability to increase microvascular permeability in the rabbit skin in vivo was isolated from fraction XIII and biochemically characterized. PNV3 has 132 amino acid residues with a calculated mel. wt of 14,475. This polypeptide showed the following N-terminal sequence: AVFAIQDQPC. Amino acid analysis indicated the presence of six disulfide bridges and a high content of Glx (20%). Pairwise comparison of PNV3 amino acid sequence with 27 other spider venom polypeptides and proteins indicated that PNV3 presents high similarity (60-70%) with other toxins (Tx2.1, Tx2.5 and Tx2.6) isolated from P. nigriventer venompt
dc.relation.ispartofToxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganismspt_BR
dc.relation.ispartofabbreviationToxiconpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued1995pt_BR
dc.date.monthofcirculationFeb.pt_BR
dc.identifier.citationToxicon. Pergamon-elsevier Science Ltd, v. 33, n. 2, n. 171, n. 178, 1995.pt_BR
dc.language.isoengpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage171pt_BR
dc.description.lastpage178pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.eissn1879-3150pt_BR
dc.identifier.doi10.1016/0041-0101(94)00148-2pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/0041010194001482pt_BR
dc.date.available2014-12-02T16:27:58Z
dc.date.available2015-11-26T16:12:30Z-
dc.date.accessioned2014-12-02T16:27:58Z
dc.date.accessioned2015-11-26T16:12:30Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:27:58Z (GMT). No. of bitstreams: 1 WOSA1995QQ04200006.pdf: 789996 bytes, checksum: 079ec4d0e80fb8f0dd1215fb3ac34e10 (MD5) Previous issue date: 1995en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:12:30Z (GMT). No. of bitstreams: 2 WOSA1995QQ04200006.pdf: 789996 bytes, checksum: 079ec4d0e80fb8f0dd1215fb3ac34e10 (MD5) WOSA1995QQ04200006.pdf.txt: 24512 bytes, checksum: 587078c159f53427e2404cb360de0961 (MD5) Previous issue date: 1995en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60847pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/60847
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60847-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.description.abstractalternative-
dc.identifier.source7597720-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.type.formArtigo originalpt_BR
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