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Type: Artigo de periódico
Title: Iodine-Catalyzed Aza-Prins Cyclization: Metal-Free Synthesis and Antiproliferative Activity of Hexahydrobenzo[f]isoquinolines
Author: Figueiredo, CAM
Reddy, KRKK
Monteiro, PA
de Carvalho, JE
Ruiz, ALTG
Silva, LF
Abstract: A series of hexahydrobenzo[f]isoquinolines were synthesized by an iodine-catalyzed aza-Prins cyclization under metal-free conditions. An aliphatic or an aromatic aldehyde can be used as the carbonyl component in this reaction, which can also be performed efficiently under solvent-free conditions. During this study, we discovered new compounds with moderate antitumor activities.
Subject: cyclizations
antitumor agents
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Rights: aberto
Identifier DOI: 10.1055/s-0032-1318478
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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