Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60610
Type: Artigo de periódico
Title: Investigation of Autonomic Function and Orocecal Transit Time in-Patients With Nonalcoholic Cirrhosis and the Potential Influence of These Factors on Disease Outcome
Author: Nagasako, CK
Figueiredo, MJD
Almeida, JRD
Lorena, SLS
Akasaka, HM
Pavan, CR
Yamanaka, A
Pereira, TS
Soares, EC
Mesquita, MA
Abstract: Background: The presence of autonomic dysfunction in nonalcoholic cirrhosis and its influence on intestinal transit and disease outcome still need clarification. Goals: To investigate the function of the autonomic nervous system in patients with nonalcoholic cirrhosis and the possible associations among autonomic dysfunction, severity of liver disease, disturbed intestinal transit, and the development of complications during follow-up. Study: Measurements of heart rate variability obtained by analysis of 24-hour ambulatory electrocardiographic recordings to assess autonomic function and lactulose breath hydrogen test to determine orocecal transit time were performed in 32 patients with nonalcoholic cirrhosis divided into Child A and B. Results: Child B patients showed significantly lower values (P < 0.05) of those parameters reflecting parasympathetic (high frequency, log-transformed high frequency, pNN50) and sympathetic function (low frequency, log-transformed low frequency) in comparison with controls and Child A patients. Orocecal transit time values were significantly (P = 0.02) higher in Child B patients than in controls, but no relationship was found between delayed orocecal transit time and autonomic dysfunction. During follow-up, 42% of Child B patients developed encephalopathy. This complication was significantly associated with autonomic dysfunction. In addition, in the 4 patients who died the parameters reflecting parasympathetic function were significantly reduced in comparison with those of survivors. Conclusions: Autonomic dysfunction and delayed intestinal transit are related to the severity of disease in nonalcoholic cirrhosis. Autonomic dysfunction seems to predispose cirrhotic patients to the development of encephalopathy and tray be associated with a poor prognosis of these patients.
Subject: nonalcoholic cirrhosis
autonomic dysfunction
encephalopathy
orocecal transit time
Country: EUA
Editor: Lippincott Williams & Wilkins
Rights: fechado
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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