Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60609
Type: Artigo de periódico
Title: Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis
Author: Scarel-Caminaga, RM
Trevilatto, PC
Souza, AP
Brito, RB
Line, SRP
Abstract: Background: Interleukin-2 (IL-2) is a pro-inflammatory cytokine derived from Th1 cells. This cytokine is involved in B-cell activation and stimulates macrophages, natural killer cells, T-cell proliferation and osteoclast activity. IL-2 has been also implicated in the stimulation of osteoclast activity in bone resorption. Objective: In this study the relationship between the polymorphism - 330 (T-->G) in the IL-2 gene and different levels of chronic periodontal disease was investigated. Materials and Methods: DNA was extracted from buccal epithelial cells of 113 unrelated adult individuals acting as controls and with different levels of periodontitis. The PCR-RFLP technique was used to investigate the polymorphism in the promoter of IL-2 gene. Results: When comparing the data of three groups of patients (Control, Moderate and Severe) we did not find significant differences between the studied IL-2 polymorphism and severity levels of PD. However, when the Control and Moderate phenotypes were grouped together and compared with genotypes TT vs. TG/GG, a significant difference was observed. Conclusion: We conclude that the - 330 (T-->G) polymorphism in the IL-2 gene is associated with the severity of periodontal disease. The results presented in this study suggest an active role of IL-2 in the pathogenesis of periodontal disease.
Subject: chronic periodontitis
interleukin-2
polymorphism
risk factors
Country: Dinamarca
Editor: Blackwell Munksgaard
Rights: fechado
Identifier DOI: 10.1034/j.1600-051X.2002.290701.x
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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