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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleIntramolecular Catalysis of Phosphodiester Hydrolysis by Two Imidazolespt_BR
dc.contributor.authorOrth, ESpt_BR
dc.contributor.authorBrandao, TASpt_BR
dc.contributor.authorSouza, BSpt_BR
dc.contributor.authorPliego, JRpt_BR
dc.contributor.authorVaz, BGpt_BR
dc.contributor.authorEberlin, MNpt_BR
dc.contributor.authorKirby, AJpt_BR
dc.contributor.authorNome, Fpt_BR
unicamp.author.emailfaruk@qmc.ufsc.brpt_BR
unicamp.authorKirby, Anthony J. Univ Chem Lab, Cambridge CB2 1EW, Englandpt_BR
unicamp.authorOrth, Elisa S. Brandao, Tiago A. S. Souza, Bruno S. Nome, Faruk Univ Fed Santa Catarina, Dept Quim, INCT Catalise, BR-88040900 Florianopolis, SC, Brazilpt_BR
unicamp.authorPliego, Josefredo R. Univ Fed Sao Joao Del Rei, BR-36301160 Sao Joao Del Rei, MG, Brazilpt_BR
unicamp.authorVaz, Boniek G. Eberlin, Marcos N. Univ Estadual Campinas, ThoMSon Mass Spectrometry Lab, Inst Chem, BR-88040900 Campinas, SP, Brazilpt_BR
dc.subject.wosGeneral-acid Catalysispt_BR
dc.subject.wosPhospholipase-d Superfamilypt_BR
dc.subject.wosBis(2,4-dinitrophenyl) Phosphatept_BR
dc.subject.wosNucleophilic-attackpt_BR
dc.subject.wosReactivity Correlationspt_BR
dc.subject.wosDiester Hydrolysispt_BR
dc.subject.wosBase Catalysispt_BR
dc.subject.wosAb-initiopt_BR
dc.subject.wosDensitypt_BR
dc.subject.wosEsterspt_BR
dc.description.abstractTwo imidazole groups act together to catalyze the hydrolysis of the phosphodiester bis(2-(1-methyl-1H-imidazolyl)phenyl) phosphate (BMIPP). A full investigation involving searching computational and electrospray ionization (ESI-MS-/MS) and ultra mass spectrometry (LTQ-FT) experiments made possible a choice between two kinetically equivalent mechanisms. The preferred pathway, involving intramolecular nucleophilic catalysis by imidazole, assisted by intramolecular general acid catalysis by the imidazolium group, offers the first simple model for the mechanism used by the extensive phospholipase D superfamily.pt
dc.relation.ispartofJournal Of The American Chemical Societypt_BR
dc.relation.ispartofabbreviationJ. Am. Chem. Soc.pt_BR
dc.publisher.cityWashingtonpt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Chemical Socpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculation45078pt_BR
dc.identifier.citationJournal Of The American Chemical Society. Amer Chemical Soc, v. 132, n. 24, n. 8513, n. 8523, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume132pt_BR
dc.description.issuenumber24pt_BR
dc.description.firstpage8513pt_BR
dc.description.lastpage8523pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0002-7863pt_BR
dc.identifier.wosidWOS:000278905700052pt_BR
dc.identifier.doi10.1021/ja1034733pt_BR
dc.description.sponsorshipINCT-Catalisept_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFAPESCpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-11-17T07:17:01Z
dc.date.available2015-11-26T16:40:53Z-
dc.date.accessioned2014-11-17T07:17:01Z
dc.date.accessioned2015-11-26T16:40:53Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:40:53Z (GMT). No. of bitstreams: 2 WOS000278905700052.pdf: 1630437 bytes, checksum: 6fcb3402976fbbf47fb1e01ec054ee8a (MD5) WOS000278905700052.pdf.txt: 50292 bytes, checksum: eb1408dd6b602d99fb34929402dc814b (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60531pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/60531
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60531-
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