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|Type:||Artigo de periódico|
|Title:||Intramolecular acid-base catalysis of a phosphate diester: Modeling the ribonuclease mechanism|
|Abstract:||The hydrolysis of the phosphate diester bis(2-(1-methyl-1H-imidazolyl)pheny) phosphate BMIPP was evaluated as an intramolecular model for the ribonuclease A mechanism. Kinetic and thermodynamic data, isotope effects and ESI-MS and ESI-MS/MS analysis support the proposed intramolecular general acid-base catalysis by the imidazole groups.|
|Editor:||Amer Chemical Soc|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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