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Type: Artigo de periódico
Title: Intramolecular acid-base catalysis of a phosphate diester: Modeling the ribonuclease mechanism
Author: Orth, ES
Brandao, TAS
Milagre, HMS
Eberlin, MN
Nome, F
Abstract: The hydrolysis of the phosphate diester bis(2-(1-methyl-1H-imidazolyl)pheny) phosphate BMIPP was evaluated as an intramolecular model for the ribonuclease A mechanism. Kinetic and thermodynamic data, isotope effects and ESI-MS and ESI-MS/MS analysis support the proposed intramolecular general acid-base catalysis by the imidazole groups.
Country: EUA
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/ja710693x
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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