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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInterlaboratory quality control, in gynecologic cytopathology using the novel CONQUISTADOR softwarept_BR
dc.contributor.authorAlderisio, Mpt_BR
dc.contributor.authorBranca, Mpt_BR
dc.contributor.authorErzen, Mpt_BR
dc.contributor.authorLongatto, Apt_BR
dc.contributor.authorDerchain, Spt_BR
dc.contributor.authorTatti, Spt_BR
dc.contributor.authorVighi, Spt_BR
dc.contributor.authorRoteli-Martins, Cpt_BR
dc.contributor.authorLeoncini, Lpt_BR
dc.contributor.authorMaeda, MYSpt_BR
dc.contributor.authorMontis, Dpt_BR
dc.contributor.authorGontijo, Rpt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorSyrjanen, Kpt_BR
unicamp.authorNatl Ctr Epidemiol Surveillance & Promot Hlth, NIH, Unit Cytopathol, Rome, Italy SIZE Diagnost Ctr, Ljubljana, Slovenia Inst Adolfo Lutz Registro, Sao Paulo, Brazil Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst, Braga, Portugal Univ Estadual Campinas, Campinas, Brazil Gynecol Hosp Clin, Buenos Aires, DF, Argentina Hosp Leonor M de Barros, Sao Paulo, Brazil Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku, Finlandpt_BR
dc.subjectdiagnostic accuracy indexpt_BR
dc.subjectquality controlpt_BR
dc.subjectPap smearpt_BR
dc.subjectperformance indicatorspt_BR
dc.subject.wosCervical Smearspt_BR
dc.subject.wosInterobserver Variabilitypt_BR
dc.description.abstractObjective The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement. among 4 cytology laboratories participating in the LAMS Study. Study Design The study was an interlaboratory exchange of specially designed 5 slide sets, each comprising 20 (conventional cytology) slides. At the first step, 80 slides (with "clear-cut" cases) were divided into four sets (A, B, C, D) of 20 specimens, each including inadequate and negative cases as well as in different proportions of all diagnostic TBS 2001 categories. In the second round, a fifth set (E) of 20 slides ("difficult cases") was designed, with all diagnostic categories, ASC and AGC included. Common measures of reproducibility (kappa and weighted kappa), accuracy (SE, SP, PPV, NPV) and 3 indices of diagnostic variability were calculated for sets A-D and set E, separately. Results For the 5 slide sets together, the weighted kappa was 0.8 (95% CI 0.76-0.85), which is the lower limit of the "almost perfect" ranking of kappa statistics, indicating an excellent interlaboratory agreement. The interlaboratory reproducibility was lower only for the difficult set (E). Similarly, the sensitivity for set E (70.0%) was lower than that (92.1%) for sets A-D. The diagnostic variability indices were not substantially different between the difficult (set E) and clear-cut (sets A-D) cases. Conclusion High interlaboratory reproducibility was obtained for sets A-D ("clear-cut" cases), while more interlaboratory variation was evident in the difficult samples. The new CONQUISTADOR software is a valuable tool in calculating the indicators needed in this intralaboratory and interlaboratory
dc.relation.ispartofActa Cytologicapt_BR
dc.relation.ispartofabbreviationActa Cytol.pt_BR
dc.publisher.citySt Louispt_BR
dc.publisherSci Printers & Publ Incpt_BR
dc.identifier.citationActa Cytologica. Sci Printers & Publ Inc, v. 51, n. 6, n. 872, n. 881, 2007.pt_BR
dc.sourceWeb of Sciencept_BR
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