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Type: Artigo de periódico
Title: Interlaboratory quality control, in gynecologic cytopathology using the novel CONQUISTADOR software
Author: Alderisio, M
Branca, M
Erzen, M
Longatto, A
Derchain, S
Tatti, S
Vighi, S
Roteli-Martins, C
Leoncini, L
Maeda, MYS
Montis, D
Gontijo, R
Sarian, LO
Syrjanen, K
Abstract: Objective The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement. among 4 cytology laboratories participating in the LAMS Study. Study Design The study was an interlaboratory exchange of specially designed 5 slide sets, each comprising 20 (conventional cytology) slides. At the first step, 80 slides (with "clear-cut" cases) were divided into four sets (A, B, C, D) of 20 specimens, each including inadequate and negative cases as well as in different proportions of all diagnostic TBS 2001 categories. In the second round, a fifth set (E) of 20 slides ("difficult cases") was designed, with all diagnostic categories, ASC and AGC included. Common measures of reproducibility (kappa and weighted kappa), accuracy (SE, SP, PPV, NPV) and 3 indices of diagnostic variability were calculated for sets A-D and set E, separately. Results For the 5 slide sets together, the weighted kappa was 0.8 (95% CI 0.76-0.85), which is the lower limit of the "almost perfect" ranking of kappa statistics, indicating an excellent interlaboratory agreement. The interlaboratory reproducibility was lower only for the difficult set (E). Similarly, the sensitivity for set E (70.0%) was lower than that (92.1%) for sets A-D. The diagnostic variability indices were not substantially different between the difficult (set E) and clear-cut (sets A-D) cases. Conclusion High interlaboratory reproducibility was obtained for sets A-D ("clear-cut" cases), while more interlaboratory variation was evident in the difficult samples. The new CONQUISTADOR software is a valuable tool in calculating the indicators needed in this intralaboratory and interlaboratory QC.
Subject: diagnostic accuracy index
quality control
Pap smear
performance indicators
Country: EUA
Editor: Sci Printers & Publ Inc
Citation: Acta Cytologica. Sci Printers & Publ Inc, v. 51, n. 6, n. 872, n. 881, 2007.
Rights: fechado
Identifier DOI: 10.1159/000325863
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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