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Type: Artigo de periódico
Title: Interferon-beta modifies the peripheral blood cell cytokine secretion in patients with multiple sclerosis
Author: Mirandola, SR
Hallal, DEM
Farias, AS
Oliveira, EC
Brandao, CO
Ruocco, HH
Damasceno, BP
Santos, LMB
Abstract: Immunotherapy with Interferon-beta (IFN beta) results in remarkably beneficial effects in patients with relapsing-remitting multiple sclerosis (MS), although the mechanisms by which it exerts these beneficial effects remain poorly understood. An investigation was made of the effects of IFN beta on pro-inflammatory and anti-inflammatory cytokine production in peripheral blood cells in MS patients, both untreated and those undergoing immunotherapy. as well as in healthy controls. Results show a significant increase in the production of pro-inflammatory cytokines such as TNF alpha, IFN gamma and IL-12 in the plasma and in the supernatant of leukocyte cultures from MS patients with the untreated disease; IFN beta administration significantly reduced the levels of TNF alpha and IFN gamma, with no changes in the level of IL-12. The Interferon-beta therapy also led to a significant increase in the production of IL-10, as well as a slight increase in that of TGF beta. The reduction in pro-inflammatory cytokine production in the treated MS patient group, accompanied by a simultaneous increase in the production of anti-inflammatory cytokines and the reduction of relapse rates suggests that the beneficial effects of IFN beta immunotherapy result. at least in part, from the modulation of cytokine patterns. (C) 2009 Elsevier B.V. All rights reserved.
Subject: Cytokines
Myelin basic protein
Country: Holanda
Editor: Elsevier Science Bv
Citation: International Immunopharmacology. Elsevier Science Bv, v. 9, n. 41858, n. 824, n. 830, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2009.03.004
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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