Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60432
Type: Artigo de periódico
Title: Interferon beta-modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion
Author: Yasuda, CL
Al-Sabbagh, A
Oliveira, EC
Diaz-Bardales, BM
Garcia, AA
Santos, LMB
Abstract: The mechanism of action underlying the beneficial effect of IFN beta in Multiple Sclerosis is poorly understood. Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for Multiple Sclerosis; therefore, we investigated the effects of recombinant mouse IFN beta on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN beta reduced the disease activity with an I.P, dosage of 10,000 U/day every other day, and successfully treated EAE mice revealed reduced amounts of IFN gamma; no changes in the levels of IL4 were observed, although thera was a significant increase in IL10 and TGF beta production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.
Country: EUA
Editor: Marcel Dekker Inc
Rights: fechado
Identifier DOI: 10.3109/08820139909061141
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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