Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60348
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDelbin, Maria Andréiapt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.typeArtigopt_BR
dc.titleInteraction between serotoninergic-and beta-adrenergic receptors signaling pathways in rat femoral arterypt_BR
dc.contributor.authorDelbin, M.A.pt_BR
dc.contributor.authorSilva, A.S.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorZanesco, A.pt_BR
dc.subjectArtéria femoralpt_BR
dc.subjectSerotoninapt_BR
dc.subjectDoença arterial periféricapt_BR
dc.subject.otherlanguagePeripheral arterial diseasept_BR
dc.subject.otherlanguageFemoral arterypt_BR
dc.subject.otherlanguageSerotoninpt_BR
dc.description.abstractCoronary heart disease has been widely studied in cardiovascular research. However, patients with peripheral artery disease (PAD) have worst outcomes compared to those with coronary artery disease. Therefore, pharmacological studies using femoral artery are highly relevant for a better understanding of the pathophysiologic responses of the PAD. Objective: The aim of this study was to evaluate the pharmacologic properties of the contractile and relaxing agents in rat femoral artery. Methods: Concentration response curves to the contractile phenylephrine (PE) and serotonin (5-HT) and the relaxing agents isoproterenol (ISO) and forskolin were obtained in isolated rat femoral artery. For relaxing responses, tissues were precontracted with PE or 5-HT. Results: The order rank potency in femoral artery was 5-HT > PE for contractile responses. In tissues precontracted with 5-HT, relaxing responses to isoproterenol was virtually abolished as compared to PE-contracted tissues. Forskolin, a stimulant of adenylyl cyclase, partially restored the relaxing response to ISO in 5-HT-precontracted tissues. Conclusion: An interaction between beta-adrenergic- and serotoninergic- receptors signaling pathway occurs in femoral artery. Moreover, this study provides a new model to study serotoninergic signaling pathway under normal and pathological conditions which can help understanding clinical outcomes in the PADpt
dc.relation.ispartofArquivos brasileiros de cardiologiapt_BR
dc.relation.ispartofabbreviationArq. bras. cardiol.pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherArquivos Brasileiros de Cardiologiapt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationJan.pt_BR
dc.identifier.citationArquivos Brasileiros De Cardiologia. Arquivos Brasileiros Cardiologia, v. 98, n. 1, n. 29, n. 34, 2012.pt_BR
dc.language.isoengpt_BR
dc.description.volume98pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage29pt_BR
dc.description.lastpage34pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0066-782Xpt_BR
dc.identifier.doi10.1590/S0066-782X2011005000121pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2012000100006pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-07-30T14:33:49Z
dc.date.available2015-11-26T16:05:59Z-
dc.date.accessioned2014-07-30T14:33:49Z
dc.date.accessioned2015-11-26T16:05:59Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:33:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:05:59Z (GMT). No. of bitstreams: 2 WOS000300058100011.pdf: 1360618 bytes, checksum: 5d42799924abc9e84bf2ea33a36b2869 (MD5) WOS000300058100011.pdf.txt: 22041 bytes, checksum: 26ec88cdd3848c11e66651127b740ae9 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60348
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60348-
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source2-s2.0-84857159113-
dc.creator.orcid0000-0002-3537-055Xpt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.type.formArtigo originalpt_BR
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000300058100011.pdf1.33 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.