Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60348
Type: Artigo de periódico
Title: Interaction between Serotoninergic-and beta-adrenergic Receptors Signaling Pathways in Rat Femoral Artery
Author: Delbin, MA
Silva, AS
Antunes, E
Zanesco, A
Abstract: Background: Coronary heart disease has been widely studied in cardiovascular research. However, patients with peripheral artery disease (PAD) have worst outcomes compared to those with coronary artery disease. Therefore, pharmacological studies using femoral artery are highly relevant for a better understanding of the pathophysiologic responses of the PAD. Objective: The aim of this study was to evaluate the pharmacologic properties of the contractile and relaxing agents in rat femoral artery. Methods: Concentration response curves to the contractile phenylephrine (PE) and serotonin (5-HT) and the relaxing agents isoproterenol (ISO) and forskolin were obtained in isolated rat femoral artery. For relaxing responses, tissues were precontracted with PE or 5-HT. Results: The order rank potency in femoral artery was 5-HT > PE for contractile responses. In tissues precontracted with 5-HT, relaxing responses to isoproterenol was virtually abolished as compared to PE-contracted tissues. Forskolin, a stimulant of adenylyl cyclase, partially restored the relaxing response to ISO in 5-HT-precontracted tissues. Conclusion: An interaction between beta-adrenergic- and serotoninergic- receptors signaling pathway occurs in femoral artery. Moreover, this study provides a new model to study serotoninergic signaling pathway under normal and pathological conditions which can help understanding clinical outcomes in the PAD. (Arq Bras Cardiol 2012;98(1):29-34)
Subject: Peripheral arterial disease
femoral artery/physiopathology
receptors
adrenergic/alpha
receptors
adrenergic/beta
receptors
serotonin
Country: Brasil
Editor: Arquivos Brasileiros Cardiologia
Rights: aberto
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000300058100011.pdf1.33 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.