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|Type:||Artigo de periódico|
|Title:||Insulin-Loaded Poly(epsilon-Caprolactone) Nanoparticles: Efficient, Sustained and Safe Insulin Delivery System|
|Author:||de Araujo, TM|
|Abstract:||The aim of this work was to develop an efficient, biodegradable, biocompatible and safe controlled release system using insulin-loaded poly(epsilon-caprolactone) (PCL) nanoparticles. The insulin-loaded PCL nanoparticles were prepared by double emulsion method (water-in-oil-in-water) using Pluronic F68 as emulsifier. Using the double emulsion method a high insulin encapsulation efficiency (90.6 +/- 1.6%) with a zeta potential of -29 +/- 2.7 mV and average particle size of 796 +/- 10.5 nm was obtained. Insulin-loaded PCL nanoparticles showed no toxicity to MIN6 cells. Insulin nanoparticles administered subcutaneously and intraperitoneally in rats reduced glycaemia of basal levels after 15 minutes, and presented a sustainable hypoglycemic effect on insulin-dependent type 1 diabetic rats, showing to be more efficient than unencapsulated insulin. Furthermore, these nanoparticles were not hepatotoxic, as evaluated by the effect over liver cell-death and oxidative stress scavenger system in rats. These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care.|
|Editor:||Amer Scientific Publishers|
|Citation:||Journal Of Biomedical Nanotechnology. Amer Scientific Publishers, v. 9, n. 6, n. 1098, n. 1106, 2013.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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