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Type: Artigo de periódico
Title: Inflammatory responses induced in mice by lectin from Talisia esculenta seeds
Author: Freire, MGM
Desouza, IA
Silva, ACM
Macedo, MLR
Lima, MS
Tamashiro, WMSC
Antunes, E
Marangoni, S
Abstract: A novel lectin from Talisia esculenta seeds (TEL) has recently been purified and characterized. In this study we investigated the proinflammatory activity of TEL in mice using both the air-pouch and peritoneal cavity as well as paw oedema models. TEL (10-40 mug) induced significant neutrophil and mononuclear cell recruitment when injected into either mouse air-pouch or peritoneal cavity. The neutrophil accumulation into the air-pouch was dose- and time-dependent with a maximal response at 16 h. returning to control levels at 72 h whereas maximal mononuclear cell accumulation was observed at 24 h after TEL injection. The same profile of neutrophil accumulation was observed when this lectin was injected into mouse peritonea] cavity, although the maximal mononuclear cell recruitment was observed 48 h after TEL injection. Additionally, TEL (12.5-200 mug/paw) caused a dose-dependent mice paw, as evaluated at 4 h after the lectin injection. D-mannose, better than D-glucose, significantly inhibited TEL-induced neutrophil migration into the peritoneal cavity or air-pouch. D-galactose had no effect on TEL-induced neutrophil migration in either cavity studied. On the other hand, D-mannose slightly inhibited the TEL-induced paw oedema. whereas neither D-glucose nor D-galactose affected this phenomenon. In conclusion, our data show that TEL induces neutrophil and mononuclear cell accumulation by a mechanism related to their specific sugar-binding properties. (C) 2003 Elsevier Ltd. All rights reserved.
Subject: Talisia esculenta lectin
mouse paw oedema
leukocyte immigration
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Toxicon. Pergamon-elsevier Science Ltd, v. 42, n. 3, n. 275, n. 280, 2003.
Rights: fechado
Identifier DOI: 10.1016/S0041-0101(03)00142-9
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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