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Type: Artigo de periódico
Title: Inflammatory and Hyperalgesic Effects of Oxidized Multi-Walled Carbon Nanotubes in Rats
Author: Pinto, NV
de Andrade, NF
Martinez, DST
Alves, OL
Souza, AG
Mota, MRL
Nascimento, KS
Cavada, BS
Assreuy, AMS
Abstract: We evaluated local inflammatory activity of oxidized multiwalled carbon nanotubes in rat experimental models of acute inflammation (paw edema and hyperalgesia) by analyzing their toxicity in non-mesoendothelial tissues. Subcutaneous injection of the nanotubes induced paw edema, that was maximal in the first 2 h after administration at 0.1 mg/kg (43.25 +/- 3.8 AUC) and 1 mg/kg (30.1 +/- 1.8 AUC) compared to saline (18.32 +/- 02.05 AUC). The histopathological analysis showed acute inflammation characterized by vasodilatation, edema formation, neutrophil infiltrate and tissue damage. The nanotubes also elicited hyperalgesic response, seen by the increase of animal paw withdrawal that was maximal in the first 3 hours. The data obtained at the 3rd h was: 75 +/- 9.3% (0.01 mg/kg), 58 +/- 8.3% (0.1 mg/kg) and 53 +/- 6.69% (1 mg/kg) in relation with saline (28 +/- 3.5%). In conclusion, the oxidized multiwalled carbon nanotubes elicit inflammatory and hyperalgesic effects associated to severe tissue damage in rats.
Subject: Oxidized Multiwalled Carbon Nanotubes
Acute Inflammation
Paw Edema
Neutrophil Infiltrate
Tissue Damage
Country: EUA
Editor: Amer Scientific Publishers
Rights: fechado
Identifier DOI: 10.1166/jnn.2013.7546
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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