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Type: Artigo de periódico
Title: Induction of immune memory following administration of a prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 L1 virus-like particle (VLP) vaccine
Author: Olsson, SE
Villa, LL
Costa, RLR
Petta, CA
Andrade, RP
Malm, C
Iversen, OE
Hoye, J
Steinwall, M
Riis-Johannessen, G
Andersson-Ellstrom, A
Elfgren, K
von Krogh, G
Lehtinen, M
Paavonen, J
Tamms, GM
Giacoletti, K
Lupinacci, L
Esser, MT
Vuocolo, SC
Saah, AJ
Barr, E
Abstract: Background: The duration of protection afforded by vaccines represents a critical test of their utility as public health interventions. Some vaccines induce long-term immunity, while others require booster doses. Vaccines that induce long-term protection are usually characterized by the generation of immune memory. Recent trials of a quadrivalent (types 6, 11, 16, 18) human papillomavirus (HPV) vaccine have demonstrated high efficacy through 5 years of follow-up. We evaluated the extent to which the vaccine is able to generate HPV type-specific immune memory. Methods: A total of 552, 16-23-year-old women were enrolled in a double-blind, placebo-controlled study. At enrollment, subjects were randomized in a 1:1 ratio to receive three-dose regimens of quadrivalent HPV vaccine or placebo with 3 years' follow-up. A subset of 241 subjects (n = 114 in the quadrivalent HPV vaccine group and n = 127 in the placebo group) underwent 2 further years of follow-up. All extension subjects received quadrivalent HPV vaccine at month 60 to examine the extent of immune memory in response to the primary vaccination series.
Subject: human papillomavirus
prophylactic vaccine
virus-like particles
cervical intraepithelial neoplasia (CIN)
genital warts
cervical cancer
clinical trial
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.vaccine.2007.03.049
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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