Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60039
Type: Artigo de periódico
Title: Increased susceptibility to Strongyloides venezuelensis infection is related to the parasite load and absence of major histocompatibility complex (MHC) class II molecules
Author: Rodrigues, RM
Cardoso, CR
Goncalves, ALR
Silva, NM
Massa, V
Alves, R
Ueta, MT
Silva, JS
Costa-Cruz, JM
Abstract: In human and murine models strongyloidiasis induce a Th2 type response. In the current study we investigated the role of different loads of Strongyloides venezuelensis in the immune response raised against the parasite and the participation of the major histocompatibility complex (MHC) class II molecule in the disease outcome in face of the different parasite burden. The C57BL/6 wild type (WT) and MHC II-/- mice were individually inoculated by subcutaneous injection with 500 or 3000 S. venezuelensis L3. The MHC II-/- mice infected with 300013 were more susceptible to S. venezuelensis infection when compared with WT groups, in which the parasite was completely eliminated. The production of Th2 cytokines and specific IgG1 or IgE antibodies against parasite were significantly lowered in MHC II-/- infected mice with different larvae inoculums. The infection of MHC II mice with S. venezuelensis induced slight inflammatory alterations in the small intestine, and these lesions were lower when compared with WT mice, irrespective of the parasite load utilized to infect animals. Finally, we concluded that MHC class II molecules are essential in the immune response against S. venezuelensis mainly when infection occurs with high parasite inoculum. (C) 2013 Elsevier Inc. All rights reserved.
Subject: Strongyloides venezuelensis
MHC class II
Strongyloidiasis
Immune response
Country: EUA
Editor: Academic Press Inc Elsevier Science
Rights: fechado
Identifier DOI: 10.1016/j.exppara.2013.09.004
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.