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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleIncreased Risk of Oncogenic Human Papillomavirus Infections and Incident High-Grade Cervical Intraepithelial Neoplasia Among Smokers Experience From the Latin American Screening Studypt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorHammes, LSpt_BR
dc.contributor.authorLongatto, Apt_BR
dc.contributor.authorGuarisi, Rpt_BR
dc.contributor.authorDerchain, SFMpt_BR
dc.contributor.authorRoteli-Martins, Cpt_BR
dc.contributor.authorNaud, Ppt_BR
dc.contributor.authorErzen, Mpt_BR
dc.contributor.authorBranca, Mpt_BR
dc.contributor.authorTatti, Spt_BR
dc.contributor.authorde Matos, JCpt_BR
dc.contributor.authorGontijo, Rpt_BR
dc.contributor.authorMaeda, MYSpt_BR
dc.contributor.authorLima, Tpt_BR
dc.contributor.authorCosta, Spt_BR
dc.contributor.authorSyrjanen, Spt_BR
dc.contributor.authorSyrjanen, Kpt_BR
unicamp.authorSarian, Luis Otavio Guarisi, Renata Derchain, Sophie F. M. Gontijo, Renata Univ Estadual Campinas, Dept Obstet & Gynecol, Fac Med Sci, Sao Paulo, Brazilpt_BR
unicamp.authorHammes, Luciano Serpa Naud, Paulo de Matos, Jean Carlos Hosp Clin Porto Alegre, Porto Alegre, RS, Brazilpt_BR
unicamp.authorLongatto-Filho, Adhemar Univ Minho, Life & Hlth Sci Res Inst, Sch Hlth Sci, Braga, Portugalpt_BR
unicamp.authorLongatto-Filho, Adhemar Inst Adolfo Lutz Registro, Sao Paulo, Brazilpt_BR
unicamp.authorRoteli-Martins, Cecilia Maeda, Marina Y. S. HLMB, Sao Paulo, Brazilpt_BR
unicamp.authorErzen, Mojca Lima, Temistocles SIZE Diagnost Ctr, Ljubljana, Sloveniapt_BR
unicamp.authorBranca, Margherita Natl Inst Hlth ISS, Unit Cytopathol, Natl Ctr Epidemiol Surveillance & Promot Hlth, Rome, Italypt_BR
unicamp.authorTatti, Silvio First Chair Gynecol Hosp Clin, Buenos Aires, DF, Argentinapt_BR
unicamp.authorCosta, Silvano St Orsola Marcello Malpighi Hosp, Dept Gynecol Obstet & Pediat Sci, Bologna, Italypt_BR
unicamp.authorSyrjanen, Stina Univ Turku, Dept Oral Pathol, Turku, Finlandpt_BR
unicamp.authorSyrjanen, Kari Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku, Finlandpt_BR
dc.subject.wosVisual Inspectionpt_BR
dc.subject.wosPooled Analysispt_BR
dc.subject.wosPositive Womenpt_BR
dc.subject.wosUterine Cervixpt_BR
dc.description.abstractBackground: The purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-HPV) infection and cervical intraepithelial neoplasia (CIN) in a large sample of Latin American women. Methods: The study examines baseline data on over 12,000 women included in the Latin American Screening Study (Brazil and Argentina). and over 1000 women followed-up for a period of 36 months. Three groups were formed: never smokers, current, and past smokers. The prevalence of hr-HPV infection and CIN were compared between the study groups. In the prospective analysis, women were controlled at 6-month intervals to assess the cumulative risk of incident hr-HPV infection. smear abnormalities. and CIN. Results: A higher prevalence (21.7%) of hr-HPV infection was found among current smokers as compared to never smokers (16.5%) or past smokers (13.5%). Being Current smoker was significantly (P <0.01) associated with hr-HPV detection (OR = 1.6: 95% CI = 1.2-2.1). Being a current smoker was a significant predictor of incident hr-HPV during the follow-up [Hazards ratio (HR) - 1.4 95% CI 1.0-1.9]. For incident CIN2+. being a past smoker (HR - 3.6: 95% CI 1.6-9.8) or current smoker (HR = 3.6 95% CI 1.5-8.6) were the significant independent predictors. Current and past smokers had a significantly increased risk of incident CIN2+ (P <0.01). Conclusions: Smoking increases the risk of contracting hr-HPV infection and modifies the effect of a persistent hr-HPV infection by further increasing the risk of developing CIN2 +. It seems that this effect modification persists over several years after smoking
dc.relation.ispartofSexually Transmitted Diseasespt_BR
dc.relation.ispartofabbreviationSex. Transm. Dis.pt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.identifier.citationSexually Transmitted Diseases. Lippincott Williams & Wilkins, v. 36, n. 4, n. 241, n. 248, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipINCO-DEV Program of the European Commission [ICA4-CT-2001-10013]pt_BR
dc.description.sponsordocumentnumberINCO-DEV Program of the European Commission [ICA4-CT-2001-10013]pt
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