Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/60034
Type: Artigo de periódico
Title: Increased Risk of Oncogenic Human Papillomavirus Infections and Incident High-Grade Cervical Intraepithelial Neoplasia Among Smokers Experience From the Latin American Screening Study
Author: Sarian, LO
Hammes, LS
Longatto, A
Guarisi, R
Derchain, SFM
Roteli-Martins, C
Naud, P
Erzen, M
Branca, M
Tatti, S
de Matos, JC
Gontijo, R
Maeda, MYS
Lima, T
Costa, S
Syrjanen, S
Syrjanen, K
Abstract: Background: The purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-HPV) infection and cervical intraepithelial neoplasia (CIN) in a large sample of Latin American women. Methods: The study examines baseline data on over 12,000 women included in the Latin American Screening Study (Brazil and Argentina). and over 1000 women followed-up for a period of 36 months. Three groups were formed: never smokers, current, and past smokers. The prevalence of hr-HPV infection and CIN were compared between the study groups. In the prospective analysis, women were controlled at 6-month intervals to assess the cumulative risk of incident hr-HPV infection. smear abnormalities. and CIN. Results: A higher prevalence (21.7%) of hr-HPV infection was found among current smokers as compared to never smokers (16.5%) or past smokers (13.5%). Being Current smoker was significantly (P <0.01) associated with hr-HPV detection (OR = 1.6: 95% CI = 1.2-2.1). Being a current smoker was a significant predictor of incident hr-HPV during the follow-up [Hazards ratio (HR) - 1.4 95% CI 1.0-1.9]. For incident CIN2+. being a past smoker (HR - 3.6: 95% CI 1.6-9.8) or current smoker (HR = 3.6 95% CI 1.5-8.6) were the significant independent predictors. Current and past smokers had a significantly increased risk of incident CIN2+ (P <0.01). Conclusions: Smoking increases the risk of contracting hr-HPV infection and modifies the effect of a persistent hr-HPV infection by further increasing the risk of developing CIN2 +. It seems that this effect modification persists over several years after smoking cessation.
Country: EUA
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/OLQ.0b013e3181935a7d
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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