Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/600
Type: Artigo de periódico
Title: Adult rats are more sensitive to the vascular effects induced by hyperhomocysteinemia than young rats
Author: ANDRADE, Claudia Roberta de
CAMPOS, Glenda Andrea Destro de
TIRAPELLI, Carlos Renato
LAURINDO, Francisco R. M.
HADDAD, Renato
EBERLIN, Marcos N.
OLIVEIRA, Ana Maria de
Abstract: We aimed to investigate the vascular effects of hyperhomocysteinemia (HHcy) on carotid arteries from young and adult rats. With this purpose young and adult rats received a solution of DL-homocysteine-thiolactone (1 g/kg body weight/day) in the drinking water for 7, 14 and 28 days. Increase on plasma homocysteine occurred in young and adult rats treated with DL-homocysteine-thiolactone in all periods. Vascular reactivity experiments using standard muscle bath procedures showed that HHcy enhanced the contractile response of endothelium-intact, carotid rings to phenylephrine in both young and adult rats. However, in young rats, the increased phenylephrine-induced contraction was observed after hyperhomocysteinemia for 14 and 28 days, whereas in adult rats this response was already apparent after 7 day treatment. HHcy impaired acetylcholine-induced relaxation in arteries from adult but not young rats. The contraction induced by phenylephrine in carotid arteries in the presence of Y-27632 was reversed to control values in arteries from young but not adult rats with hyperhomocysteinemia. HHcy did not alter the contraction induced by CaCl(2) in carotid arteries from young rats, but enhanced CaCl(2)-induced contraction in the arteries from adult rats. HHcy increased the basal levels of superoxide anion in arteries from both groups. Finally, HHcy decreased the basal levels of nitrite in arteries from adult but not young rats. The major new finding of the present work is that arteries from young rats are more resistant to vascular changes evoked by HHcy than arteries from adult rats. Also, we verified that the enhanced vascular response to phenylephrine observed in carotid arteries of DL-homocysteine thiolactone-treated rats is mediated by different mechanisms in young and adult rats. (C) 2010 Published by Elsevier Inc.
Subject: Hyperhomocysteinemia
Rat carotid artery
Young
Aging
Vascular reactivity
Country: Estados Unidos
Editor: ELSEVIER SCIENCE INC
Citation: VASCULAR PHARMACOLOGY, v.53, n.3/Abr, p.99-106, 2010
Rights: fechado
Identifier DOI: 10.1016/j.vph.2010.04.006
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000281837600004&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1016/j.vph.2010.04.006
Date Issue: 2010
Appears in Collections:IQ - Artigos e Materiais de Revistas Científicas

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