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Type: Artigo de periódico
Title: Pleomorphic adenoma of the submandibular gland - Clinicopathological and immunohistochemical features of 60 cases in Brazil
Author: Alves, FA
Perez, DEC
Almeia, OP
Lopes, MA
Kowalski, LP
Abstract: The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were women. Tumor sizes varied from I to 10 cm and the mean time between symptom onset and treatment was 52 months. Only I patient experienced local recurrence, 3 years after treatment. Histologically, most tumors consisted chiefly in a chondromyxoid stroma. Stroma-rich PAs were larger than stroma-poor ones (P<.02). All PAs were found negative for Ki-67 and p53. These results show that PAs of the submandibular gland are histologically similar to PAs of other salivary glands, and that they have a low proliferative rate and a good prognosis.
Country: EUA
Editor: Amer Medical Assoc
Rights: fechado
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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