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|Type:||Artigo de periódico|
|Title:||PLASMID CODING FOR DRUG-RESISTANCE AND INVASION OF EPITHELIAL-CELLS IN ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-|
|Abstract:||Enteropathogenic Escherichia coli (EPEC) can adhere to, invade and multiply in human epithelial cells. To define the elements required for bacterial invasion, we isolated from an 0111:H- EPEC a 6.6 kb plasmid that is capable of conferring to an avirulent, non-adherent E. coli K12 strain (DK1) the capacity to invade epithelial cells. With this system a dissociation was possible between bacterial invasion and adherence to epithelial cells. Bacteria containing this plasmid synthesise a protein of 32 kDa (pi 4.93) which seemed to be required for cell invasion. The results provide a new basis for strategies to prevent EPEC infections.|
|Editor:||Academic Press (london) Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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