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Type: Artigo de periódico
Title: Plasma hydroxy metronidazole/metronidarole ratio in anti-HCV carriers with and without apparent liver disease
Author: da Silva, CMF
David, FL
Muscara, MN
Sousa, SS
Ferraz, JGP
de Nucci, G
Polimeno, NC
Pedrazzoli, J
Abstract: Aims To evaluate plasma hydroxy-metronidazole/metronidazole ratio as a dynamic liver function test in HCV-infected individuals with/without Liver disease, in the absence of liver cirrhosis. Methods Metronidazole was administered intravenously in healthy volunteers, asymptomatic anti-HCV-positive blood donors, and in chronic hepatitis C patients. Serology to HCV was determined by a second generation assay and confirmed by gelatin particle agglutination test using recombinant antigens C22-3 and C200, Plasma concentration of metronidazole and hydroxy-metronidazole was measured by high performance liquid chromatography in samples collected 5, 10, 20 and 30 min following the end of metronidazole infusion. Results Chronic hepatitis: patients had abnormal liver enzymes, while healthy Volunteers and anti-HCV-positive blood donors had normal Liver biochemistry tests. Plasma metronidazole concentration was similar in all groups studied. Plasma Hydroxy-metronidazole/metronidazole ratio was significantly reduced in HCV-infected subjects, an effect observed 10 min after the end of drug infusion. Conclusions Metronidazole clearance is impaired in anti-HCV-positive blood donors and chronic hepatitis C patients, indicating that HCV is capable of affecting liver function at early stages of the disease. The metronidazole clearance test can detect impaired liver function in HCV-infected individuals even in the absence of liver cirrhosis.
Subject: metronidazole clearance
Liver function,
hepatitis C
cytochrome P450
blood donors
Country: Inglaterra
Editor: Blackwell Science Ltd
Citation: British Journal Of Clinical Pharmacology. Blackwell Science Ltd, v. 46, n. 2, n. 176, n. 180, 1998.
Rights: fechado
Identifier DOI: 10.1046/j.1365-2125.1998.00758.x
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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