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Type: Artigo de periódico
Title: Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-gamma-cyclodextrin inclusion complex
Author: Macedo, OFL
Andrade, GRS
Conegero, LS
Barreto, LS
Costa, NB
Gimenez, IF
Almeida, LE
Kubota, D
Abstract: Here we report the preparation of a trimethoprim/2-hydroxypropyl-gamma-cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 degrees C and 35 degrees C) that the association constants decrease with increasing temperature. Values for K-1:1 constant were of the same magnitude order of those found for the parent gamma-CD. The inclusion orientation as evidenced by ROESY measurements involves the inclusion of the 3.45-trimethoxybenzyl ring in the CD cavity from the larger rim. This is in agreement with semiempirical molecular modeling calculation. (C) 2011 Elsevier B.V. All rights reserved.
Subject: Trimethoprim
Inclusion complex
Phase-solubility diagram
Molecular modeling
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.saa.2011.10.010
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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