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Type: Artigo de periódico
Title: Phylogenetic comparison of the carboxy-terminal region of glycoprotein C (gC) of bovine herpesviruses (BoHV) 1.1, 1.2. and 5 from South America (SA)
Author: Esteves, PA
Dellagostin, OA
Pinto, LS
Silva, AD
Spilki, FR
Ciacci-Zanella, JR
Hubner, SO
Puentes, R
Maisonnavee, J
Franco, AC
Rijsewijk, FAM
Batista, HBCR
Teixeira, TF
Dezen, D
Oliveira, AP
David, C
Arns, CW
Roehe, PM
Abstract: Different types and subtypes of bovine herpesvirus 1 and 5 (BoHV-1 and BoHV-5) have been associated to different clinical conditions of cattle, in such a way that type/subtype differentiation has become an essential too] for understanding the pathogenesis and epidemiology of BoHV infections. In search for a genomic region that would allow a clear distinction between BoHV-1 and BoHV-5, the carboxy-terminal portion of glycoprotein C (gC), corresponding to residues 321-450 (BoHV-1) and 301-429 (BoHV-5) of 23 South American (SA) isolates (Brazil mostly) was amplified and sequenced. The nucleotide sequence alignments revealed levels of genomic similarity ranging from 98.7 to 99.8% among BoHV-1 isolates, 88.3 to 92% between BoHV-1/BoHV-5 and 96 to 99.7% among BoHV-5 isolates. At the amino acid level, sequence similarity varied ranging from 97.5 to 99.5% among BoHV-1, 77.5 to 84.4% between BoHV-1/BoHV-5 and 92.1 to 99.5% (BoHV-5/BoHV-5). The isolates could be clearly separated into BoHV-1.1, BoHV-1.2 and BoHV-5 after phylogenetic analysis. The results suggest that the phylogenetic analysis performed here can be used as a potential molecular epidemiological tool for herpesviruses. (c) 2007 Elsevier B.V. All rights reserved.
Subject: BoHV-1
glycoprotein C
phylogenetic analysis
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.virusres.2007.08.004
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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