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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePharmacological characterization of the mouse paw edema induced by staphylococcal enterotoxin Bpt_BR
dc.contributor.authorDesouza, IApt_BR
dc.contributor.authorBergdoll, MSpt_BR
dc.contributor.authorRiberioDaSilva, Gpt_BR
unicamp.authorUNIV WISCONSIN,DEPT FOOD MICROBIOL & TOXICOL,INST FOOD RES,MADISON,WI 53706 STATE UNIV CAMPINAS,FAC MED SCI,DEPT PHARMACOL,BR-13084100 CAMPINAS,SP,BRAZILpt_BR
dc.subject.wosPlatelet Activating Factorpt_BR
dc.subject.wosCysteinyl Leukotrienespt_BR
dc.subject.wosArachidonic-acidpt_BR
dc.subject.wosUnsensitized Monkeyspt_BR
dc.subject.wosInflammationpt_BR
dc.subject.wosMediatorspt_BR
dc.subject.wosSkinpt_BR
dc.subject.wosAntagonistpt_BR
dc.subject.wosInhibitionpt_BR
dc.description.abstractStaphylococcal enterotoxin B (SEE) induced a long-lasting dose- and time-dependent edema in the mouse hind paw. The edematogenic response was biphasic and consisted of a primary (early) phase which lasted approximately 24 h and a secondary (late) phase which started after 24 h and continued for up to 72 h. There was a positive correlation between the measured edema and the amount of Evans blue dye extravasation produced by SEE, suggesting that this exudate is the principal component of the edema. Arachidonic acid metabolites contribute to the SEE-induced edema with lipoxygenase products being involved in the early phase, while cyclooxygenase products are involved in the late phase. The early phase edema was partially prevented by pretreating the mice with WEB 2086 (a PAF antagonist), capsaicin (to deplete sensory C-fibers of their neuropeptides), or histamine receptor (H-1 or H-2) antagonists. Based on the similarities between the SEE-induced edema in mice and the vomiting and cutaneous ''pseudoallergy'' produced by this toxin in monkeys, our results suggest that mice may prove to be a useful model for studying SE-mediated enterotoxemia.pt
dc.relation.ispartofJournal Of Natural Toxinspt_BR
dc.relation.ispartofabbreviationJ. Nat. Toxinspt_BR
dc.publisher.cityFt Collinspt_BR
dc.publisherAlaken, Incpt_BR
dc.date.issued1996pt_BR
dc.date.monthofcirculationFEBpt_BR
dc.identifier.citationJournal Of Natural Toxins. Alaken, Inc, v. 5, n. 1, n. 61, n. 71, 1996.pt_BR
dc.language.isoenpt_BR
dc.description.volume5pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage61pt_BR
dc.description.lastpage71pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1058-8108pt_BR
dc.identifier.wosidWOS:A1996TW83400006pt_BR
dc.date.available2014-07-30T14:31:23Z
dc.date.available2015-11-26T16:39:01Z-
dc.date.accessioned2014-07-30T14:31:23Z
dc.date.accessioned2015-11-26T16:39:01Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:31:23Z (GMT). No. of bitstreams: 0 Previous issue date: 1996en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:39:01Z (GMT). No. of bitstreams: 0 Previous issue date: 1996en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59411
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59411-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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