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|Type:||Artigo de periódico|
|Title:||Pharmacological characterization of the mouse paw edema induced by staphylococcal enterotoxin B|
|Abstract:||Staphylococcal enterotoxin B (SEE) induced a long-lasting dose- and time-dependent edema in the mouse hind paw. The edematogenic response was biphasic and consisted of a primary (early) phase which lasted approximately 24 h and a secondary (late) phase which started after 24 h and continued for up to 72 h. There was a positive correlation between the measured edema and the amount of Evans blue dye extravasation produced by SEE, suggesting that this exudate is the principal component of the edema. Arachidonic acid metabolites contribute to the SEE-induced edema with lipoxygenase products being involved in the early phase, while cyclooxygenase products are involved in the late phase. The early phase edema was partially prevented by pretreating the mice with WEB 2086 (a PAF antagonist), capsaicin (to deplete sensory C-fibers of their neuropeptides), or histamine receptor (H-1 or H-2) antagonists. Based on the similarities between the SEE-induced edema in mice and the vomiting and cutaneous ''pseudoallergy'' produced by this toxin in monkeys, our results suggest that mice may prove to be a useful model for studying SE-mediated enterotoxemia.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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