Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59400
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMendes, Gustavo Duartept_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampFaro, Renato do Rego de Araujopt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.typeArtigopt_BR
dc.titlePharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beaglespt_BR
dc.contributor.authorOkuyama, C.E.pt_BR
dc.contributor.authorMendes, G.D.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorAstigarraga, R.E.B.pt_BR
dc.contributor.authorFaro, R.pt_BR
dc.contributor.authorLagos, R.M.pt_BR
dc.contributor.authorRezende, V.M.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
unicamp.author.emailcris_okuyama@yahoo.com.brpt_BR
unicamp.authorUniv Estadual Campinas, Dept Pharmacol, Fac Med Sci, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectHipertensãopt_BR
dc.subject.otherlanguageHypertensionpt_BR
dc.subject.wosConverting-enzyme-inhibitorpt_BR
dc.subject.wosRenin-angiotensin Systempt_BR
dc.subject.wosArginine Methyl-esterpt_BR
dc.subject.wosAnesthetized Dogspt_BR
dc.subject.wosVascular-resistancept_BR
dc.subject.wosS-nitrosocaptoprilpt_BR
dc.subject.wosCardiac-outputpt_BR
dc.subject.wosHypertensionpt_BR
dc.subject.wosRatspt_BR
dc.subject.wosDrugspt_BR
dc.description.abstractPharmacological compounds that release nitric oxide (NO) have been useful tools in the evaluation of the broad role of NO in physiopathology and therapeutics. The present study compared the pharmacokinetics and pharmacodynamics of enalapril and an NO-releasing enalapril molecule (NCX899) in conscious male beagles. The effects of both enalapril and NCX899 in the arterial hypertension and bradycardia induced by acute NO inhibition in anaesthetized dogs were also investigated. 2. Dogs received either NCX899 (4 mu mol/kg, i.v.) or enalapril (4 mu mol/kg, i.v.), after which plasma concentrations of the analytes and metabolites were quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). 3. In the NCX899 group, the area under the time-course curve (AUC(0-24h)) was 29.18 +/- 4.72, 229.37 +/- 51.32 and 5159.23 +/- 514.88 mu g.h/L for the analytes nitro-enalapril, enalapril and enalaprilat, respectively. In the enalapril group, the AUC(0-24h) was 704.53 +/- 158.86 and 4149.27 +/- 847.30 mu g.h/L for the analytes enalapril and enalaprilat, respectively. Statistical analysis of data from both groups showed a significant difference for the analyte enalapril, but not for enalaprilat. Moreover, NCX899 and enalapril were equally effective in inhibiting the activity of serum angiotensin-converting enzyme. 4. In anaesthetized dogs, i.v. administration of the NO synthase (NOS) inhibitor N-G-nitro-L-arginine methyl ester (L-NAME; 0.1-10 mg/kg) significantly elevated arterial blood pressure, with concomitant bradycardia. The compound NCX899 significantly attenuated both arterial hypertension and bradycardia, whereas enalapril had no significant effect. 5. In conclusion, the present results showed that the NO-releasing derivative of enalapril NCX899 presents a pharmacokinetic/pharmacodynamic relationship similar to its parent compound enalapril. Moreover, NCX899 (but not enalapril) was effective in protecting against the cardiovascular changes induced by acute NOS inhibitionpt
dc.relation.ispartofClinical and experimental pharmacology and physiologypt_BR
dc.relation.ispartofabbreviationClin. exp. pharmacol. physiol.pt_BR
dc.publisher.cityCarltonpt_BR
dc.publisher.countryAustraliapt_BR
dc.publisherBlackwell Sciencept_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationApr.pt_BR
dc.identifier.citationClinical And Experimental Pharmacology And Physiology. Blackwell Publishing, v. 34, n. 4, n. 290, n. 295, 2007.pt_BR
dc.language.isoengpt_BR
dc.description.volume34pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage290pt_BR
dc.description.lastpage295pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.sourceWOSpt_br
dc.identifier.issn0305-1870pt_BR
dc.identifier.wosidWOS:000244227000007pt_BR
dc.identifier.doi10.1111/j.1440-1681.2007.04559.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1681.2007.04559.xpt_BR
dc.description.sponsorshipFAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.date.available2014-11-16T01:20:22Z
dc.date.available2015-11-26T16:31:14Z-
dc.date.accessioned2014-11-16T01:20:22Z
dc.date.accessioned2015-11-26T16:31:14Z-
dc.description.provenanceMade available in DSpace on 2014-11-16T01:20:22Z (GMT). No. of bitstreams: 1 WOS000244227000007.pdf: 167637 bytes, checksum: 8c8ab71cd262f0ae0cfbf72fa7855af0 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:31:14Z (GMT). No. of bitstreams: 2 WOS000244227000007.pdf: 167637 bytes, checksum: 8c8ab71cd262f0ae0cfbf72fa7855af0 (MD5) WOS000244227000007.pdf.txt: 31074 bytes, checksum: 05c1346bd61fcee9146c4eb07752626a (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59400pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/59400
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59400-
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source244227000007-
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.type.formArtigo original-
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000244227000007.pdf163.71 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.