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|Title:||Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats|
|Author:||Tofoli, G. R.|
Cereda, C. M. S.
de Araujo, D. R.
de Paula, E.
Brito, R. B.
Barros, F. A. P.
Groppo, F. C.
Volpato, M. C.
|Abstract:||The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3% mepivacaine (MVC(3%)), and 2% liposome-encapsulated mepivacaine (MVC(LUV)). The results showed that the 2% liposome-encapsulated mepivacaine reduced C(max), prolonged AUC(0-infinity) and t(1/2) compared with 3% plain and 2% vasoconstritor-associated mepivacaine, after intraoral injection. In addition, it was also observed that liposomal mepivacaine might protect the tissue against local inflammation evoked by plain or vasoconstrictors-associated mepivacaine, giving supporting evidence for its safety and possible clinical use in dentistry|
|Editor:||Taylor & Francis|
|Citation:||Drug Delivery. Taylor & Francis Inc, v. 17, n. 2, n. 68, n. 76, 2010.|
|Appears in Collections:||FOP - Artigos e Outros Documentos|
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