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Type: Artigo de periódico
Title: Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats
Author: Tofoli, GR
Cereda, CMS
de Araujo, DR
de Paula, E
Brito, RB
Pedrazzoli, J
Meurer, E
Barros, FAP
Groppo, FC
Volpato, MC
Ranali, J
Abstract: The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3% mepivacaine (MVC(3%)), and 2% liposome-encapsulated mepivacaine (MVC(LUV)). The results showed that the 2% liposome-encapsulated mepivacaine reduced C(max), prolonged AUC(0-infinity) and t(1/2) compared with 3% plain and 2% vasoconstritor-associated mepivacaine, after intraoral injection. In addition, it was also observed that liposomal mepivacaine might protect the tissue against local inflammation evoked by plain or vasoconstrictors-associated mepivacaine, giving supporting evidence for its safety and possible clinical use in dentistry.
Subject: Local anesthetics
local toxicity
Country: EUA
Editor: Taylor & Francis Inc
Rights: fechado
Identifier DOI: 10.3109/10717540903508995
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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