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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePersistent High-Risk Human Papillomavirus Infections and Other End-Point Markers of Progressive Cervical Disease Among Women Prospectively Followed up in the New Independent States of the Former Soviet Union and the Latin American Screening Study Cohortspt_BR
dc.contributor.authorSyrjanen, Kpt_BR
dc.contributor.authorShabalova, Ipt_BR
dc.contributor.authorNaud, Ppt_BR
dc.contributor.authorKozachenko, Vpt_BR
dc.contributor.authorDerchain, Spt_BR
dc.contributor.authorZakharchenko, Spt_BR
dc.contributor.authorRoteli-Martins, Cpt_BR
dc.contributor.authorNerovjna, Rpt_BR
dc.contributor.authorLongatto, Apt_BR
dc.contributor.authorKljukina, Lpt_BR
dc.contributor.authorTatti, Spt_BR
dc.contributor.authorBranovskaja, Mpt_BR
dc.contributor.authorHammes, LSpt_BR
dc.contributor.authorBranca, Mpt_BR
dc.contributor.authorGrunjberga, Vpt_BR
dc.contributor.authorErzen, Mpt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorJuschenko, Apt_BR
dc.contributor.authorCosta, Spt_BR
dc.contributor.authorPodistov, Jpt_BR
dc.contributor.authorSyrjanen, Spt_BR
unicamp.authorSyrjanen, Kari Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20521 Turku, Finlandpt_BR
unicamp.authorShabalova, Irena Kozachenko, Vladimir Russian Acad Postgrad Med Educ, Moscow, Russiapt_BR
unicamp.authorNaud, Paulo Hammes, Luciano Serpa Hosp Clin, Porto Alegre, RS, Brazilpt_BR
unicamp.authorNaud, Paulo Hammes, Luciano Serpa Univ Fed Rio Grande do Sul, Dept Gynecol & Obstet, Porto Alegre, RS, Brazilpt_BR
unicamp.authorDerchain, Sophie Sarian, Luis Otavio Univ Estadual Campinas, Campinas, SP, Brazilpt_BR
unicamp.authorZakharchenko, Sergej Novgorod Municipal Dermatovenereol Dispensary, Dept Gynaecol, Novgorod, Russiapt_BR
unicamp.authorRoteli-Martins, Cecilia Hosp Leonor M de Barros, Sao Paulo, Brazilpt_BR
unicamp.authorNerovjna, Raisa Novgorod Female Consultat Outpatient Hosp, Dept Gynaecol, Novgorod, Russiapt_BR
unicamp.authorLongatto-Filho, Adhemar Inst Adolfo Lutz Registro, Sao Paulo, Brazilpt_BR
unicamp.authorLongatto-Filho, Adhemar Univ Minho, Life & Hlth Sci Res Inst, Sch Hlth Sci, Braga, Portugalpt_BR
unicamp.authorKljukina, Ludmila Republican Ctr Clin Cytol, Oncol & Med Radiol Res Inst, Minsk, Byelaruspt_BR
unicamp.authorTatti, Silvio First Chair Gynecol Hosp Clin, Buenos Aires, DF, Argentinapt_BR
unicamp.authorBranovskaja, Marina Minsk State Med Inst, Dept Obstet & Gynaecol, Minsk, Byelaruspt_BR
unicamp.authorBranca, Margherita Natl Inst Hlth ISS, Unit Cytopathol, Natl Ctr Epidemiol Surveillance & Promot Hlth, Rome, Italypt_BR
unicamp.authorGrunjberga, Valerija Juschenko, Anna Lab Cytol, Riga, Latviapt_BR
unicamp.authorErzen, Mojca SIZE Diagnost Ctr, Ljubljana, Sloveniapt_BR
unicamp.authorCosta, Silvano St Orsola Marcello Malpighi Hosp, Dept Obstet & Gynecol, Bologna, Italypt_BR
unicamp.authorPodistov, Jurij Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow, Russiapt_BR
unicamp.authorSyrjanen, Stina Univ Turku, Dept Oral Pathol, Inst Dent, Turku, Finlandpt_BR
dc.subjectCervical infectionspt_BR
dc.subjectProspective follow-uppt_BR
dc.subjectIntermediate end pointspt_BR
dc.subjectNIS cohortpt_BR
dc.subjectLAMS studypt_BR
dc.subject.wosCytologically Normal Womenpt_BR
dc.subject.wosSquamous Intraepithelial Lesionspt_BR
dc.subject.wosPap-smear Abnormalitiespt_BR
dc.subject.wosLow-resource Settingspt_BR
dc.subject.wosHpv Infectionspt_BR
dc.subject.wosVisual Inspectionpt_BR
dc.subject.wosAbsolute Riskpt_BR
dc.description.abstractBackground: New end points are needed in future human papillomavirus (HPV) vaccine efficacy studies that accurately predict disease progression. Objectives: Potential intermediate end points were analyzed in the combined New Independent States of the Former Soviet Union (NIS) and the Latin American Screening (LAMS) study cohorts. Study Design and Methods: Data files of 2 international screening trials, the NIS (n = 3187) and the LAMS (n = 12,114) study cohorts, were combined, and a subcohort of 1865 (n = 854 and n 10 11 for the NIS and the LAMS, respectively) women prospectively followed up for 19.7 (median, 22.2) months was analyzed for different intermediate end-point markers of disease progression to squamous intraepithelial lesion (SIL), cervical intraepithelial neoplasia grade I and higher (CIN1+), and CIN grade 2 and higher (CIN2+) as terminal events. Results: Altogether, 131 (7.0%), 90 (4.8%), and 39 (2.1%) cases progressed to SIL, CIN 1+, and CIN2+, respectively, progression times being equal in the NIS (11.9, 16.8, and 19.6 months) and LAMS (13.6, 14.1, and 15.4 months) cohorts (P = 0.931, P = 0.335, and P = 0.535). The 2 most powerful end-point markers of disease progression to CIN2+ were high-grade squamous intraepithelial lesions based on Papanicolaou test results at 6-month (odds ratio [OR] = 47.1; 95% confidence interval [Cl], 17.3-128.7) and 12-tilonth (OR = 21.5; 95% CI, 5.1-90.8) follow-up Visits, With longitudinal positive and negative predictive values of 42.1% and 98.0% (6 months) and 33.3% and 97.7% (12 months). Of the virological end points, more than 6 months of persistent high-risk HPV (HR-HPV) was the most powerful predictor of progression to CIN1+ (OR = 18.6; 95% CI, 2.5-136.5), with longitudinal positive and negative predictive values of 10.3% and 99.4%, respectively. No additional benefit was obtained using more than 12 months of persistent HR-HPV end point. Conclusions: High-grade squamous intraepithelial lesion based on a Papanicolaou test results at 6- or 12-month follow-up Visits was the most powerful end point, either considering cytological end points alone or in comparison to any of the virological end points. Of the virological end points, more than 6-month HR-HPV persistence criteria give the most powerful estimate of a progressive
dc.relation.ispartofInternational Journal Of Gynecological Cancerpt_BR
dc.relation.ispartofabbreviationInt. J. Gynecol. Cancerpt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.identifier.citationInternational Journal Of Gynecological Cancer. Lippincott Williams & Wilkins, v. 19, n. 5, n. 934, n. 942, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.provenanceMade available in DSpace on 2014-07-30T14:31:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:40:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
Appears in Collections:Unicamp - Artigos e Outros Documentos

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