Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59362
Type: Artigo de periódico
Title: Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands
Author: Demasi, APD
Furuse, C
Altemani, A
Junqueira, JLC
Oliveira, PRG
Araujo, VC
Abstract: Background: Oncocytic lesions, particularly frequent in the salivary glands, are characterized by cells with an atypical accumulation of mitochondria. This accumulation has been recognized as a compensatory mechanism to intrinsic functional defects of these organelles, resulting in energy production impairment and increased generation of reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)). Peroxiredoxin I (Prx I) is a H(2)O(2) scavenging protein and the expression of its yeast homolog was reported to be influenced by mitochondrial function. Methods: In this study, we evaluated Prx I expression in oncocytic lesions of salivary glands by immunohistochemistry. Results: Our results showed that Prx I is overexpressed in oncocytes regardless of the salivary gland lesion where they appear. Conclusions: These results suggest that Prx I expression in oncocytes is related to its ability to decompose mitochondrial-derived H(2)O(2) and that it could provide to the cells a protective role in an environment that, by continuously producing potential DNA-damaging ROS, predisposes to genome instability and cellular transformation.
Subject: immunohistochemistry
mitochondria
oncocytes
peroxiredoxins
salivary gland
Country: EUA
Editor: Wiley-blackwell Publishing, Inc
Rights: fechado
Identifier DOI: 10.1111/j.1600-0714.2009.00753.x
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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