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Type: Artigo de periódico
Title: Permeability transition pore closure promoted by quinine
Author: Catisti, R
Vercesi, AE
Abstract: The mitochondrial membrane permeability transition induced by Ca2+ is inhibited by quinine in a dose-dependent fashion. Competition experiments strongly suggest that quinine displaces Ca2+ bound to the inner membrane. This is supported by experiments showing that quinine inhibits Ca2+-dependent but not Ca2+-independent mitochondrial swelling induced by phenylarsine oxide. As with Ca2+ chelators, quinine induces permeability transition pore closure preventing the contraction induced by poly(ethylene glycol) 2000 in mitochondria preswollen by incubation in KSCN medium containing Ca2+ and inorganic phosphate,These results suggest that quinine dislodges Ca2+ bound to the protein site, which triggers pore opening.
Subject: rat liver mitochondria
membrane permeability transition
calcium ion
Country: EUA
Editor: Kluwer Academic/plenum Publ
Rights: fechado
Identifier DOI: 10.1023/A:1005455912711
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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