Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59341
Type: Artigo de periódico
Title: PERIPHERAL-NERVE REPAIR USING A POLY(ORGANO)PHOSPHAZENE TUBULAR PROSTHESIS
Author: LANGONE, F
LORA, S
VERONESE, FM
CALICETI, P
PARNIGOTTO, PP
VALENTI, F
PALMA, G
Abstract: Nerve regeneration experiments were carried out using tubular nerve guides of poly[(ethylalanato)(1.4)(imidazolyl)(0.6)phosphazene] (PEIP). By means of in vivo tests, this polymer was found to be biodegradable and transformed into harmless products. The tubular nerve guides were prepared by deposition of the dissolved polymer on a glass capillary tube, followed by evaporation of the solvent (methylene dichloride). After transectioning, rat sciatic nerve stumps were immediately sutured into the ends of 10-mm-long polymer tubes. On removal bf the prosthesis, after implantation for 45 d, a tissue cable was found bridging the nerve stumps in all cases. Histological analysis revealed that the tissue cable was essentially composed of a regenerated nerve fibre bundle. A parallel series of experiments was undertaken to compare the use of silicone tubes that are not biodegradable and are most frequently used for studies of nerve regeneration with tubulization techniques, The advantages of biodegradable PEIP tubular nerve guides used for peripheral nerve repair are discussed.
Subject: POLYPHOSPHAZENE
BIODEGRADATION
TUBULAR PROSTHESIS
PERIPHERAL NERVE REPAIR
NERVE REGENERATION
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/0142-9612(95)93851-4
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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