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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePeri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarctionpt_BR
dc.contributor.authorSilva, JCQEpt_BR
dc.contributor.authorCoelho, ORpt_BR
dc.contributor.authorAndrade, JMpt_BR
dc.contributor.authorQuinaglia, Tpt_BR
dc.contributor.authorModolo, RGPpt_BR
dc.contributor.authorAlmeida, BOpt_BR
dc.contributor.authorvan der Geest, RJpt_BR
dc.contributor.authorJerosch-Herold, Mpt_BR
dc.contributor.authorCoelho, ORpt_BR
dc.contributor.authorSposito, ACpt_BR
unicamp.author.emailandreisposito@gmail.compt_BR
unicamp.authorCoelho-Filho, Otavio Rizzi Quinaglia, Thiago Modolo, Rodrigo G. P. Almeida, Breno O. Coelho, Otavio Rizzi Sposito, Andrei C. State Univ Campinas UNICAMP, Fac Med Sci, BR-13084971 Campinas, SP, Brazilpt_BR
unicamp.authorCoelho-Filho, Otavio Rizzi Jerosch-Herold, Michael Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USApt_BR
unicamp.authorQuinaglia e Silva, Jose C. Andrade, Joalbo M. Univ Brasilia, Med Sch UnB, Brasilia, DF, Brazilpt_BR
unicamp.authorvan der Geest, Rob J. Leiden Univ, Med Ctr, Div Image Proc, Dept Radiol, Leiden, Netherlandspt_BR
unicamp.authorQuinaglia e Silva, Jose C. Hosp Base Dist Fed, Brasilia, DF, Brazilpt_BR
unicamp.authorSposito, Andrei C. State Univ Campinas UNICAMP, Fac Med Sci, Div Cardiol, BR-13084971 Campinas, SP, Brazilpt_BR
dc.subjectmyocardial infarctionpt_BR
dc.subjectinflammationpt_BR
dc.subjectmagnetic resonance imagingpt_BR
dc.subjectperi-infarct zonept_BR
dc.subject.wosMortalitypt_BR
dc.subject.wosHeterogeneitypt_BR
dc.subject.wosApoptosispt_BR
dc.subject.wosCytokinespt_BR
dc.description.abstractEnhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 +/- 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type alpha (TNF-alpha; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-alpha (r = 0.5), delta-TNF-alpha (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ.pt
dc.relation.ispartofInflammationpt_BR
dc.relation.ispartofabbreviationInflammationpt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherSpringer/plenum Publisherspt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationInflammation. Springer/plenum Publishers, v. 37, n. 3, n. 678, n. 685, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume37pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage678pt_BR
dc.description.lastpage685pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0360-3997pt_BR
dc.identifier.eissn1573-2576pt_BR
dc.identifier.wosidWOS:000336397900005pt_BR
dc.identifier.doi10.1007/s10753-013-9784-ypt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipAHA Postdoctoral Fellowship Award [AHA 11POST5550053]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberCNPq [300313/2007-1]pt
dc.description.sponsordocumentnumberAHA Postdoctoral Fellowship Award [AHA 11POST5550053]pt
dc.date.available2014-07-30T14:31:11Z
dc.date.available2015-11-26T16:26:49Z-
dc.date.accessioned2014-07-30T14:31:11Z
dc.date.accessioned2015-11-26T16:26:49Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:31:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:26:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59299
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59299-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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