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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePerforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHDpt_BR
dc.contributor.authorPimentel, VNpt_BR
dc.contributor.authorde Matos, LSpt_BR
dc.contributor.authorSoares, TCBpt_BR
dc.contributor.authorAdam, Rpt_BR
dc.contributor.authorMetze, Kpt_BR
dc.contributor.authorCorrea, MEPpt_BR
dc.contributor.authorde Souza, CApt_BR
dc.contributor.authorCintra, MLpt_BR
unicamp.author.emailmarialet@fcm.unicamp.brpt_BR
unicamp.authorPimentel, Vanessa Nascimento de Matos, Lissa Sabino Benetti Soares, Tania Cristina Adam, Randall Metze, Konradin Cintra, Maria Leticia Univ Estadual Campinas, Sch Med, Dept Pathol, Campinas, Brazilpt_BR
unicamp.authorPizzigatti Correa, Maria Elvira de Souza, Carmino Antonio Univ Estadual Campinas, Sch Med, Hemoctr, Campinas, Brazilpt_BR
dc.subjectapoptosispt_BR
dc.subjectbone marrow transplantationpt_BR
dc.subjectcytotoxic granulespt_BR
dc.subjectlichenoidpt_BR
dc.subjectpathogenesispt_BR
dc.subject.wosVersus-host-diseasept_BR
dc.subject.wosImmunohistochemical Analysispt_BR
dc.subject.wosT-cellspt_BR
dc.subject.wosApoptosispt_BR
dc.subject.wosLymphocytespt_BR
dc.subject.wosCytotoxicitypt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosPathwaypt_BR
dc.subject.wosMucosapt_BR
dc.subject.wosDeathpt_BR
dc.description.abstractBackground: Oral lesions of lichen planus and chronic graft-vs.-host disease (cGVHD) have similar clinical and histological features, but distinct etiology. Apoptosis induced by cytotoxic T lymphocyte has been proposed as a mechanism of keratinocytes death. Cytotoxicity can be mediated by granules containing granzyme B and perforin. Since common features can reflect similarities in immunological mechanisms, we studied the role of those molecules in both diseases. Methods: We analyzed 29 cases of oral lichen planus and 27 of oral cGVHD. The sections were studied on H&E, perforin and granzyme B staining. Results: The total means (epithelium plus connective tissue number) of the granzyme B- and perforin-positive cells were significantly higher in cGVHD than in oral lichen planus lesions (P < 0.05). Also, it was found that the higher the number of perforin+ cells, the higher the number of granzyme-B+ cells in the epithelium and in the connective tissue for both groups (P < 0.05). In oral lichen planus, the number of single apoptotic bodies had a positive correlation with connective tissue granzyme immunostaining and a negative correlation with perforin (P < 0.01). On the contrary, in oral cGVHD, the number of apoptotic body clusters presented a positive correlation with connective tissue perforin (P < 0.01). Conclusions: Our findings indicate that apoptosis in oral lichen planus seems to be correlated with granzyme B release, while in oral cGVHD, perforin seems to be more important. Although these diseases present clinical and histological similarities, subtle differences seem to exist in their pathogenetic mechanisms.pt
dc.relation.ispartofJournal Of Oral Pathology & Medicinept_BR
dc.relation.ispartofabbreviationJ. Oral Pathol. Med.pt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationJournal Of Oral Pathology & Medicine. Wiley-blackwell, v. 39, n. 10, n. 741, n. 746, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume39pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage741pt_BR
dc.description.lastpage746pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.wosidWOS:000283600100003pt_BR
dc.identifier.doi10.1111/j.1600-0714.2010.00917.xpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-11-16T20:35:47Z
dc.date.available2015-11-26T16:25:15Z-
dc.date.accessioned2014-11-16T20:35:47Z
dc.date.accessioned2015-11-26T16:25:15Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:25:15Z (GMT). No. of bitstreams: 2 WOS000283600100003.pdf: 412174 bytes, checksum: 89d3065aed95ecabac8ba8d1759883ae (MD5) WOS000283600100003.pdf.txt: 26909 bytes, checksum: 521f29d51ebe4f91ef5055d2356744bf (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59234pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/59234
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59234-
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