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Type: Artigo de periódico
Title: Paucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential
Author: Lopes, SCP
Albrecht, L
Carvalho, BO
Siqueira, AM
Thomson-Luque, R
Nogueira, PA
Fernandez-Becerra, C
del Portillo, HA
Russell, BM
Renia, L
Lacerda, MVG
Costa, FTM
Abstract: There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.
Subject: malaria
Plasmodium vivax
Country: EUA
Editor: Oxford Univ Press Inc
Rights: fechado
Identifier DOI: 10.1093/infdis/jiu018
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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