Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59156
Type: Artigo de periódico
Title: Pattern of cytokine secretion by peripheral blood cells of patients with multiple sclerosis in Brazil
Author: da Costa, PM
Yasuda, CL
Scagliusi, SM
Diaz-Bardales, BM
Maciel, E
Damasceno, BP
Blotta, MHSL
Tilbery, CP
Santos, LMB
Abstract: Autoimmune T cells play a key role as regulators and effecters of organ-specific autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components produce a plethora of inflammatory cytokines and mediators that contribute to myelin damage. The production of proinflammatory and regulatory cytokines by peripheral blood cells from patients with active and stable MS and healthy controls were examined The results show that TNF alpha production was somewhat elevated in active MS with no significant increase in the level IFN gamma, whereas in the chronic phase the anti-inflammatory cytokines IL-10 and TGF-beta increased, accompanied by a reduction in IFN gamma when stimulated by myelin basic protein.
Subject: cytokines
myelin basic protein
autoimmunity
Country: Inglaterra
Editor: Nature Publishing Group
Rights: fechado
Identifier DOI: 10.1177/135245850000600501
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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