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Type: Artigo de periódico
Title: Participation of the mitochondrial permeability transition pore in nitric oxide-induced plant cell death
Author: Saviani, EE
Orsi, CH
Oliveira, JFP
Pinto-Maglio, CAF
Salgado, I
Abstract: In the present study, we investigated the involvement of the mitochondrial permeability transition pore (PTP) in nitric oxide (NO)-induced plant cell death. NO donors such as sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine inhibited growth and caused death in suspension-cultured cells of Citrus sinensis. Cells treated with SNP showed chromatin condensation and fragmentation, characteristic of apoptosis. SNP caused loss of the mitochondrial membrane electrical potential, which was prevented by cyclosporin A (CsA), a specific inhibitor of PTP formation. CsA also prevented the nuclear apoptosis and subsequent Citrus cell death induced by NO. These findings indicate that mitochondrial PTP formation is involved in the signaling pathway by which NO induces apoptosis in cultured Citrus cells. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Subject: nitric oxide
programmed cell death
mitochondrial permeability transition pore
Citrus cell
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0014-5793(01)03230-6
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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