Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59079
Type: Artigo de periódico
Title: Partial chemical and functional characterization of milk whey products obtained by different processes
Author: Ziegler, FL
Castro, GA
Moreno, YMF
Oya, V
Vilela, MMD
Sgarbieri, VC
Abstract: Whey protein samples (S-1 to S-5) were tested in vivo and in vitro for nutritional properties and selected bioactivities. Weanling male Wistar rats fed modified AIN-93G (12 g protein. 100 g(-1)) diets for 21 days were used the in vivo studies. The nutritional parameters did not differ among the protein diets tested. Erythrocyte glutathione content was considered high and was higher for S-3, but liver glutathione was the same for all dietary groups. For S-3, cytokine secretion (IL-10 and TNF-alpha) by human peripheral blood mononuclear cells (in RPMI-1640 medium) was higher in the absence of antigen than in the presence of BCG antigen. Interleukin-4 secretion was repressed in all treatments. The IC50, whey protein concentration required to inhibit 50% of the melanoma cell proliferation, was 2.68 mg.mL(-1) of culture medium for the S-3 sample and 3.66 mg.mL(-1) for the S-2 sample. Based on these results, it was concluded that S-3 (whey protein concentrate enriched with TGF-beta and lactoferrin) produced better nutritional and immunological responses than the other products tested.
Subject: whey proteins
nutritive value
immune modulation
glutathione
cytokines
Country: Brasil
Editor: Soc Brasileira Ciencia Tecnologia Alimentos
Rights: aberto
Identifier DOI: 10.1590/S0101-20612012005000002
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000304352700009.pdf516.29 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.