Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59024
Type: Artigo de periódico
Title: PARAFAC: A chemometric tool for multi-dimensional data treatment. Applications in direct determination of drugs in human plasma by spectrofluorimetry.
Author: Sena, MM
Trevisan, MG
Poppi, RJ
Abstract: Since the last decade, the combined use of chemometrics and molecular spectroscopic techniques has become a new alternative for direct drug determination, without the need of physical separation. Among the new methodologies developed, the application of PARAFAC in the decomposition of spectrofluorimetric data should be highlighted. The first objective of this article is to describe the theoretical basis of PARAFAC. For this purpose, a discussion about the order of chemometric methods used in multivariate calibration and the development of multi-dimensional methods is presented first. The other objective of this article is to divulge for the Brazilian chemical community the potential of the combination PARAFAC/spectrofluorimetry for the determination of drugs in complex biological matrices. For this purpose, two applications aiming at determining, respectively, doxorrubicine and salicylate in human plasma are presented.
Subject: parallel factor analysis
human blood
molecular fluorescence
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Identifier DOI: 10.1590/S0100-40422005000500032
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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