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|Type:||Artigo de periódico|
|Title:||Ozonolysis of Morita-Baylis-Hillman adducts originated from aromatic aldehydes: an expeditious diastereoselective approach for the preparation of alpha,beta-dihydroxy-esters|
de Souza, MFL
|Abstract:||We disclose herein ozonolysis of Morita-Baylis-Hillman adducts originated from aromatic aldehydes. This efficient reaction provides alpha-ketoesters with different substitution patterns on the aromatic ring. Diastercoselective reduction of the corresponding alpha-ketoester obtained in the oxidative cleavage step provides alpha,beta-dihydroxy-esters with excellent degree of anti diastereoselection. The method is simple and easy to execute and is therefore a valuable alternative to prepare either alpha-ketoesters or alpha-dihydroxy-esters. (c) 2007 Elsevier Ltd. All rights reserved.|
|Editor:||Pergamon-elsevier Science Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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