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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleReactivity of mesenteric and aortic rings from trained rats fed with high caloric dietpt_BR
dc.contributor.authorde Moraes, Cpt_BR
dc.contributor.authorCamargo, EApt_BR
dc.contributor.authorAntunes, Ept_BR
dc.contributor.authorde Nucci, Gpt_BR
dc.contributor.authorZanesco, Apt_BR
unicamp.author.emailazanesco@rc.unesp.brpt_BR
unicamp.authorUNESP, Dept Phys Educ, Rio Claro, SP, Brazil Univ Estadual Campinas, Dept Pharmacol, Campinas, SP, Brazilpt_BR
dc.subjectexercise trainingpt_BR
dc.subjecthigh caloric dietpt_BR
dc.subjectvascular reactivitypt_BR
dc.subjectmesentericpt_BR
dc.subjectaortapt_BR
dc.subjectnitric oxidept_BR
dc.subjectendotheliumpt_BR
dc.subject.wosEndothelium-dependent Relaxationpt_BR
dc.subject.wosHigh-density-lipoproteinspt_BR
dc.subject.wosNitric-oxidept_BR
dc.subject.wosInsulin-resistancept_BR
dc.subject.wosFatty-acidspt_BR
dc.subject.wosExercisept_BR
dc.subject.wosDysfunctionpt_BR
dc.subject.wosCholesterolpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosHypertriglyceridemiapt_BR
dc.description.abstractA strong association between the benefits of physical exercise on the cardiovascular disease with an improvement of the endothelium-derived relaxing factor production has been consistently shown. The purpose of this study was to evaluate the effect of exercise training associated with high caloric diet in the reactivity of rat mesenteric and aortic rings. Experimental protocol consisted of 4 weeks of high caloric diet consumption previous to 4 weeks of run training (1.2 km/h, 0% grade, in sessions of 60 min, 5 days/week). Concentrations of triglycerides, glucose, insulin and nitrite/nitrate levels were measured and atherogenic index was calculated. Concentration-response curves to acetylcholine (10 nM-100 mu M), sodium nitroprusside (100 pM-100 nM) and phenylephrine (1 nM-3 mu M) were obtained. Exercise training reduced body mass (6%) and triglyceride levels (about 54%), without changes in glucose and insulin concentrations. An improvement of endothelium-dependent relaxation responses to acetylcholine in mesenteric and aortic rings was observed in trained group. No changes were seen for sodium nitroprusside and phenylephrine. In conclusion, our study is the first to show clearly that run training promotes an improvement of the endothelium-dependent relaxing response in aorta and mesenteric rings from rats fed with high caloric diet and that is associated with increase of NO production. (c) 2006 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofComparative Biochemistry And Physiology A-molecular & Integrative Physiologypt_BR
dc.relation.ispartofabbreviationComp. Biochem. Physiol. A-Mol. Integr. Physiol.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherElsevier Science Incpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationComparative Biochemistry And Physiology A-molecular & Integrative Physiology. Elsevier Science Inc, v. 147, n. 3, n. 788, n. 792, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume147pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage788pt_BR
dc.description.lastpage792pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn1095-6433pt_BR
dc.identifier.wosidWOS:000247360500022pt_BR
dc.identifier.doi10.1016/j.cbpa.2006.10.018pt_BR
dc.date.available2014-11-19T05:11:13Z
dc.date.available2015-11-26T17:57:41Z-
dc.date.accessioned2014-11-19T05:11:13Z
dc.date.accessioned2015-11-26T17:57:41Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:57:41Z (GMT). No. of bitstreams: 2 WOS000247360500022.pdf: 228003 bytes, checksum: 3d8088fe4ace523da587adb721bbf893 (MD5) WOS000247360500022.pdf.txt: 26719 bytes, checksum: 1db4afcfb2ce285fe329ce51e2b02c65 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58948pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/58948
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58948-
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