Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58880
Type: Artigo de periódico
Title: Ranitidine is unable to maintain gastric pH levels above 4 in septic patients
Author: Coelho, CBT
Dragosavac, D
Neto, JSC
Montes, CG
Guerrazzi, F
Andreollo, NA
Abstract: Purpose: The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >= 4 in septic patients. Materials and methods: Twenty intensive care unit patients from a university teaching hospital with sepsis were included in this study. Ten patients received ranitidine (50 mg as an intermittent bolus 3 times a day) and 10 received pantoprazole (40 mg as an intermittent bolus twice a day). Gastric pH was measured continuously for 48 hours. Endoscopy of the upper digestive tract, gastric biopsy, and investigation for Helicobacter pylori were carried out before and at the end of the study. Results: pH values >= 4 were maintained for 46.27% +/- 38.21% and 81.57% +/- 19.65% of study time in the ranitidine and pantoprazole groups, respectively (P = .04). Conclusions: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4. (C) 2009 Published by Elsevier Inc.
Subject: Stress ulcer prophylaxis
Septic patients
Mechanical ventilation
Gastrointestinal bleeding
Histamine-2 receptor antagonists
Proton pump inhibitors
Country: EUA
Editor: W B Saunders Co-elsevier Inc
Rights: fechado
Identifier DOI: 10.1016/j.jcrc.2009.02.012
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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