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Type: Artigo de periódico
Title: Quantitative assessment of changes in blood CO2 tension mediated by the Haldane effect
Author: Giovannini, I
Chiarla, C
Boldrini, G
Terzi, R
Abstract: Adequate assessment of circulatory and gas-exchange interactions may involve the quantification of the Haldane effect (HE) and of the changes in blood Pco(2) mediated by changes in Hb-O-2 saturation and O-2-linked CO2 binding. This is commonly prevented by the complexity of the involved calculations. To simplify the task, a large series of patient measurements has been processed by regression analysis, thus developing an accurate fit for this quantification (v-a) Pco(2HE) = 0.460 [<a-v) HbO(2))]0.999(e)0.015(PvCO(2))-0.856(Hct) (n = 247, r(2) = 0.99, P << 0.0011, where (v-a)Pco(2HE) is the reduction in venous PCO2 (PVCO2, Torr) allowed by the chemical binding of CO2 in blood due to the HE (Torr), (a-v)HbO(2) is the arteriovenous difference in Hb-bound O-2 (ml/dl), and Hct is hematocrit fraction. Values of(v-a)PCO2HE estimated by this expression compared well with. the results of previously published experiments. This formula is useful in assessing the impact of HE on Pv(CO2) and venoarterial PCO2 gradient and the survival advantage offered by HE in extreme conditions. Use may be extended to all investigative and clinical settings in which changes in blood O-2 saturation and O-2-linked CO2 binding must be converted into the corresponding changes in dissolved CO2 and PCO2.
Subject: carbon dioxide exchange
circulatory failure
respiratory failure
venous hypercapnia
Country: EUA
Editor: Amer Physiological Soc
Rights: fechado
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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