Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58616
Type: Artigo de periódico
Title: Quantifying adsorption of heparin on a PVC substrate using ATR-FTIR
Author: Harada, NS
Oyama, HT
Bartoli, JR
Gouvea, D
Cestari, IA
Wang, SH
Abstract: The surface modification of poly(vinyl chloride) (PVC) tubing by heparin was performed to increase its blood compatibility. A solution of benzalkonium heparinate was used in the treatment of two types of plasticized PVC. The modification of the PVC surface was monitored after various treatment conditions, and quantitative results were obtained by using ATR-FTIR spectroscopy. The treatment times and the PVC type have a strong influence on the observed amount of heparin. A partial removal (20-30 %) of heparin was observed after rinsing the PVC surface with a 0.9wt% NaCl aqueous solution. The more flexible PVC tubing, having a lower T-g, had a higher concentration of heparin. Final heparin concentrations on the PVC surfaces were found to be in the range 1-17 mug cm(-2). (C) 2004 Society of Chemical Industry.
Subject: polyvinyl chloride)
(PVC)
heparin
infrared spectroscopy
surface modification
Country: Inglaterra
Editor: John Wiley & Sons Ltd
Rights: fechado
Identifier DOI: 10.1002/pi.1685
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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